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An in-depth comprehension of the interplay between mitochondrial dysfunction and oxidative stress, inflammation, and aging, along with their impacts in disease and therapies, will enhance understanding of these diseases and make better clinical decisions (Fig

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In the overall analysis of IC 50 sensitivity versus differentiation state, we combined p values by first adapting Browns method, a more conservative extension of Fishers method, to account for reduced independence of testing the same cell lines using different inhibitors (Poole et al., 2016)