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Emerging multi-omics insights reveal how curcumin fine-tunes cancer cell metabolism, immune checkpoints, and even microbial ecosystems, positioning it as a uniquely adaptable agent in the quest for personalized oncology solutions

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On the other hand, in the Rotterdam study, a prospective population-based cohort study by Geleijnse et al

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Finally, in vitro delivery of FTH1 siRNA in patient xenograft-derived CSCs from GBM and suppression of FTH1 (and thus decreased iron availability) resulted in reduced CSC viability, most likely due to overwhelming oxidative stress in these cells [120]