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And under phosphoserine aminotransferase 1 (PSAT1), it is converted into phosphoserine, all while also generating -KG ( In tumors, glutamine derived -KG serves as a replenishing substrate to re - activate the inhibited TCA cycle in tumor cells, thus allowing cancer cells to rely on glutamine

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In azoles, resistance is commonly attributed to overexpression of efflux pumps (particularly in Candida ) and alterations in the sterol biosynthesis pathway (Lee et al., 2021)

Congenital IGF-I deficiency tends to confer protection against post-natal development of malignancies