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Chronic liver inflammation, often from toxins or a poor diet, can contribute to more significant liver issues over time

Treatment with 10 M UA did not alter chondrogenic gene expression but led to a reduction in pro-inflammatory cytokines and cartilage-degrading enzymes, alongside an upregulation of chondrogenic markers Collagen Type II and Aggrecan (36)

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However, these natural lines of defense in mitochondria can be altered after excessive consumption of or exposure to alcohol (ethanol) [85, 94], drugs [66, 102, 103], viruses [104], and some nutrients, including fructose [105]

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For example, Zhao et al