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W., Huang H., and Zhao Y

Differences in TS diagnostic criteria between Burch and Wartofsky (56) and Akamizu et al (55) are reported in Table 4

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While initial experiments demonstrated the involvement of endogenous peroxynitrite and protein tyrosine nitration in apoptosis of motoneurons in culture, further work in ALS animal models confirmed the formation of 3-nitrotyrosine and protein-derived radicals in spinal cord motor neurons during disease progression (54, 55)