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Notably, like proteasome inhibitors, high-dose AUR also transcriptionally induces ChaC1, the rate-limiting enzyme in glutathione (GSH) catabolism [27]

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[DOI] [PubMed] [Google Scholar] Kavanagh JJ, Spriggs D, Bookman M, Ozols R, Gershenson DM, Han J, Lewis L, Brown GL, Dombrowski J, Maack C, Macpherson J, Lane A, Woodrow P and Henner WD

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Identification of immunoglobulin G autoantibody against malondialdehyde-acetaldehyde adducts as a novel serological biomarker for ulcerative colitis

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