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The comorbidity spectrum encompasses epilepsy, anxiety, sensory abnormalities, and other multisystem disorders, necessitating comprehensive strategies targeting GABA receptors, ion channel regulation, and the gut-brain axis ( 4.4 The application of GABAergic drugs in the treatment of ASD 4.4.1 GABA receptor agonists In the clinical treatment of ASD, the application of GABA receptor agonists is becoming increasingly widespread

These cells stimulate the recruitment of additional effector cells such as cytotoxic T cells and NK cells, which contribute to tissue injury through direct cytotoxicity or the release of proinflammatory cytokines and chemokines such as TNF, IL-1, IL-2, IL-12, IL-17, IFN-, CCL2, CCL3, CCL4, and CCL5

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IGFBP5 level is not altered, but it exists mostly in the fragmented form

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