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Metabolic B12 deficiency is prevalent, impacting 10%-40% of the population

10.1016/j.jhep.2020.04.038 132 SoutoJ

This elevation in NAD+ activates SIRT1, a master regulator of metabolic pathways that promotes fat oxidation, enhances mitochondrial function, and improves insulin sensitivity

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Wrong diagnosis Neurological, psychological, metabolic, and hematological symptoms seen in B12 deficiency can be caused by other disease conditions