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Post that, Novartis has requested the FDA for a label update

At present, it is very difficult to establish a clear demarcation line between beneficial and virulent species, being some problematic traits more linked to strain than to species

SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, et al

10.1016/j.bbagen.2016.03.013 Biochim

13 Another hallmark of post-traumatic DD is the over-expression of matrix-catabolic enzymes of the matrix metalloproteinases family (MMPs), especially of MMP1, -3, -13, which are all collagenases

doi: 10.1186/s12864-024-10800-6, 37 TakadaS.MaekawaS.FurihataT.KakutaniN.SetoyamaD.UedaK.et al