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Laboratory studies utilizing controlled research protocols show significant improvements in structural markers, collagen organization, and cellular regeneration processes

While the translational potential of Nrf2-targeted interventions is considerable, challenges remain, including risks of overactivation and oncogenicity, lack of reliable biomarkers, and barriers related to bloodbrain barrier permeability, dose, timing, and bioavailability

Here, we discovered that SLC25A39, a mitochondrial transporter critical for mitochondrial glutathione uptake, is a short-lived protein under dual regulation at the protein level

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