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Oral distribution : First-pass hepatic exposure means higher initial liver concentrations, which may be advantageous or disadvantageous depending on research objectives

Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, et al

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Ans: Lethargy, poor appetite, weight loss, a dull coat, skin issues, and anemia can all point toward low B12 levels in pets