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Indian J Biochem Biophys

Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants

GH binding to its receptor (GH-R) triggers receptor dimerization and activation of the Janus kinase 2 (JAK2), initiating several intracellular signaling cascades, including signal transducer and activator of transcription (STAT), phosphatidylinositol 3-kinase (PI3-K), and mitogen-activated protein kinase (MAPK) pathways [6]

These molecules can be used as adjuvant treatment to reduce the amount of prescription medication needed (Chattopadhyaya et al., 2015, Koppula et al., 2012, Sedaghat et al., 2014)

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