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The value of GSH/GSSG ratio is universally accepted as index of cell redox status because of the scavenging effect of GSH against several reactive oxygen species (e.g., hydroxyl radical: OH, superoxide anion: O 2 , hydrogen peroxide: H 2 O 2 , lipid peroxyl radical: HOO), either directly or through the activity of antioxidant enzymes, mainly the glutathione peroxidases

Epub 2020 Apr 15

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Regulating excessive excitation of ANS, reducing inflammation and oxidative stress may be the focus of preventing and treating myocardial injury after AIS

However, excessive ROS production following ablation of de novo glutathione (GSH) synthesis suppresses the activity of mammalian target of rapamycin and the expression of transcription factors NFAT and c-MYC, the latter of which control metabolic reprogramming following T cell activation (47, 48)

Surprisingly, the timing of the urinary and salivary cortisol peak after the stressor was found to be very similar