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Y-X S, Konopleva M, Munsell M, Marini FC, Steelman LS, McCubrey JA, Andreeff M

cepa was able to inhibit PLA enzyme 76% and neutralize PLA2 hydrolytic activity at a rate of 50% at all concentrations, but it failed to inhibit 5-nucleotidases activity (35-37)

Recently, a strategy based on an -ketoamide structure to construct a novel H 2 O 2 -responsive nitrogen mustard prodrug KAM-2 has been reported by the Yin group (Figure 7A) (Meng et al., 2019)

Glutamine could delay fatigue by several mechanisms: (i) it is one of the most abundant glycogenic amino acids in humans and animals, having a significant influence on the anaplerosis of the Krebs cycle and gluconeogenesis [14,15], (ii) through the activation of glycogen synthase, glutamine is considered as a direct stimulator of glycogen synthesis [7,16], (iii) this amino acid is the main non-toxic ammonia carrier, avoiding the accumulation of this metabolite [14], (iv) glutamine is also linked to attenuation of muscle damage and is considered an indirect antioxidant via stimulation of glutathione synthesis [17,18], among others

Their smooth stainless-steel surface and fine bevel reduce contamination when injecting into agar plates or culture vials

As free radicals are produced during normal physiological processes, antioxidant defense mechanisms must be in place to prevent the accumulation of these reactive species