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10.1038/s41551-018-0343-6 121 LiuQ.YaoJ.HuangZ.WangS.JiangJ.CaoY.et al (2023)

[13] Most mammalian isoenzymes have affinity for the substrate 1-chloro-2,4-dinitrobenzene, and spectrophotometric assays utilising this substrate are commonly used to report GST activity

Collagen is a protein, and if you take it with a large, protein-heavy meal, it has to compete with other amino acids for transport into the bloodstream
In contrast, in vivo models introduce essential biological complexity, making it difficult to isolate the primary mechanical signal from secondary inflammationa key methodological challenge

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Do not spray all the way up the nose
