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Continuous oxidative stress can lead to chronic inflammation, intense cytokine release and a cytokine storm as seen in SARS-CoV-2 infection in COVID-19 disease, and the viral infection enhances oxidative stress creating a fatal vicious circle between oxidative stress and cytokine storm during COVID-19 infection (Delgado-Roche and Mesta, 2020

The levels of serum IL-8, TNF-, SOD3, and GPX1 were assessed before therapy, as well as at one and two months after treatment, in both cohorts

while curcumin exerts potent anti-inflammatory, antiproliferative, and anti-angiogenic effects by blocking the NF-B pathway and downregulating VEGF expression (113)

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