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Gaucher, F
P.BrodskyI
Platelet activation by PVL-treated neutrophils is blocked by -defensin inhibitors We next set out to identify which of the substances released by PVL-lysed neutrophils drive platelet activation
In terms of off-target effects, only a limited number of these IN trials found any of note, attesting to the targeted nature of this route of delivery
The bacterial pellet was resuspended in 20 mL of lysis buffer (50 mM Tris, 1% TritonX-100, 150 mM NaCl, 5 mM MgCl 2 , 1 mM DTT, pH 7.5) and disrupted by sonication
