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10.1016/j.tice.2014.12.002 190 TambeV.PujariR.KarnikA.DongreP

The first evidence that eNOS uncoupling may be a pathophysiologically relevant phenomenon was provided by in vitro studies in which it was demonstrated that native low-density lipoprotein 81 and even more pronounced oxidized low-density lipoprotein 82 are able to stimulate endothelial superoxide production and that this phenomenon is inhibited by the NOS inhibitor N G -nitro-L-arginine methyl ester, pointing to a causal role for eNOS in superoxide production

Despite these promising findings, significant gaps remain

However, rapid or excessive increases in iodine in previously iodine-deficient populations can inadvertently induce hyperthyroidism in some individuals

Preparation of ibuprofen/hydroxypropyl--cyclodextrin inclusion complexes using supercritical CO2-assisted spray drying

Hammoud A