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2022;150(10S):41S-48S
Adv Exp med Biol [Internet]
We have a family of enzymes who use this antioxidant pipeline to generate superoxide called NADPH Oxidases (NOX)
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Stimulated by growth factors, ROS act as secondary messenger molecules and initiate a signal cascade in receptor transduction, acting downstream of small guanosine triphosphate (GTP)-binding proteins and receptor tyrosine kinases (RTKs) and upstream of the mitogen-activated protein kinase (MAPK) family (Wada and Penninger, 2004)
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