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AZD6244 (Selumetinib), a MEK1/2 inhibitor showed efficacy in BT-40 xenografts, highlighting the MEK signaling pathway as a potential therapeutic target (51)
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Gen Comp Endocrinol 299:113696 He Y, Yang T, Du Y, Qin L, Ma F, Wu Z, Ling H, Yang L, Wang Z, Zhou Q, Ge G, Lu Y (2020) High-fat diet significantly changed the global gene expression profile involved in hepatic drug metabolism and pharmacokinetic system in mice

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