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Glycyl-l-histidyl-l-lysine (GHK) is a tripeptide known for its high binding affinity to Cu The structure of GHK is very similar to that of common drugs used to treat ulcers

10.1016/S1097-2765(02)00688-3 [DOI] [PubMed] [Google Scholar] Carter CW, Wills PR

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Many formulas use cooling hydrogel technology that hugs the skin, helping ingredients remain in contact with the undereye area longerand, perhaps just as importantly, preventing the patches from slowly migrating down your cheeks