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On the right, the selenium-dependent glutathione peroxidase oxidizes two molecules of GSH back to GSSG in a reaction that converts one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)

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In p21-deficient tumor cells exposed to DNA-damaging agents, apoptosis occurs rapidly, whereas cells with enforced p21 expression survive despite accumulating damage 32