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It can bind to VEGF-A to inhibit the activity of VEGF and block its interaction with VEGFR-1 and VEGFR-2 (82), including endothelial cell enhanced vascular permeability activity, mitogenic activity and other pro-angiogenic activities, to inhibit tumor angiogenesis (81)

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Indeed, in Hgf- or Met-null mice, the development of liver is severely impaired and the placental labyrinth is hypomorphic, leading to death in utero (Bladt et al., 1995

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Jiang L, Yin M, Xu J, et al
