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Only recently fatigue has been included among the most important symptoms in cancer patients, and its evaluation is still not routinely included among the symptoms attributable to the toxicity of chemotherapy [67]

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Less appetite, sometimes weight loss

Careful longitudinal clinical and imaging monitoring were recommended using MRI and FDG-PET to identify lesions of greatest concern to be biopsied

Sega sponsored the group's "Wonder 3" tour, painting Sonic on the tour bus, distributing pamphlets advertising the game, and having footage of the game broadcast above stage prior to its release

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