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As of Week 144, the development of genotypic resistance to elvitegravir, emtricitabine, or TAF was observed in 12 of 22 subjects with evaluable resistance data from paired baseline and GENVOYA treatment-failure isolates (12 of 866 subjects [1.4%]) compared with 13 of 20 treatment-failure isolates from subjects with evaluable resistance data in the STRIBILD treatment group (13 of 867 subjects [1.5%])

Therefore, carnitine excretion by the kidney is usually very low

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO/TNF-alpha and caspase 3 activities

Therefore, inhibiting CYP7A1 affects bile acid's ability to eliminate cholesterol and other lipids, leading to the accumulation of total cholesterol, low-density lipoprotein, and triglycerides, which promotes hepatic fat accumulation and the formation of atherosclerotic plaques (Tang et al., 2013)