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We do know that in the active site of peroxiredoxins, where the reaction of H 2 O 2 with a thiolate can occur up to six orders of magnitude faster than with glutathione in its thiolate form, the reaction can occur

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Elevated ROS levels lead to lipid peroxidation, resulting in the formation of toxic aldehydes that damage neuronal membranes [179]

I will follow up in this column with more about Caloric Restriction, which is the clearest example of hormesis