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Kyal shares his wealth of knowledge and personal experiences, delving into how these powerful compounds can revolutionise our approach to health, especially for those of us dealing with chronic gut issues like Crohn's Disease

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It inhibits the expression of specific target genes by interacting with nuclear receptors, thereby regulating the development of hair follicles and the hair cycle

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Also, because checkerboard-derived FICIs can vary with method (inoculum, endpoint, extract standardization) and may not fully predict in vivo interactions, we recommend completing FICI calculations by retrieving partner-MICs (or performing two-dimensional checkerboards) and confirming promising combinations with time-kill studies or PK/PD modeling prior to claiming clinical-relevant synergy (Bentley, 2024)