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Figure 1 Pharmacodynamic mechanisms Cisplatin modulates several signal transduction pathways involving AKT (v-akt murine thymoma viral oncogene homolog), c-ABL (v-abl Abelson murine leukemia viral oncogene homolog 1), p53, and MAPK (mitogen-activated protein kinase)/JNK (c-Jun NH2-terminal kinase)/ERK (extracellular signal-regulated kinase)

Aging Much has been written concerning the plausible inverse correlation between the generation of free radicals and subsequent ROS and the longevity of an organism

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Kantor B, Bayer M, Ma H, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Hsiao Y., Shao Y., Wu Y., Hsu W., Cheng K., Yu C., Chou C., Hsieh C