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doi: 10.2174/1381612826666200424180139

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Severe, long-standing damage may take longer or may be permanent, which is why early treatment matters

Checking lyophilized vial integrity after shipping: Open the box, confirm vials are not broken, check for loose caps or visible moisture inside the vial (indicates a seal breach), and confirm the powder is still a dry, uniform cake or fluffy powder

While these conditions differ in underlying causes, both result in joint pain, stiffness, reduced mobility, and progressive tissue damage