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These methodological flaws tend to limit the usefulness of the research

[DOI] [PubMed] [Google Scholar] 271.Velsek L., Velskov J., Chudomel O., Poon K.L., Robeson K., Marshall B., Sharma A., Mosh S.L

Many patients experience increased energy, improved mood, and enhanced vitality immediately

, Han, S

Pain relief is desirable in and of itself, of course, but it may be just as critical for patients to participate actively in a rehabilitative exercise program supervised initially by physical therapy

Additionally, the observation that changes in symptoms as assessed by PainDetect are correlated with changes in the CNFD in the ARA 290 treatment group alone, further support a functional relationship between small fiber density and neuropathic symptoms