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In conclusion, accumulated evidence supports the existence of several sex differences in expression and activity of BBB transporters, and a further modulating role of gonadal hormones

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The abnormally expression of HER2 can form homodimers or heterodimers with family proteins to activate the tyrosine kinase domain, and further activate the phosphorylation cascade of downstream signaling pathways 46

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Thus, we propose that activation of TP53 by FH-derived peptides mainly occurs indirectly by inhibition of the TP53 inhibitor domain, CR3

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