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You are coming off a stretch of stress, travel, or poor sleep

This 30-60 minute pre-bed window allows adequate time for subcutaneous absorption, peptide circulation to the pituitary, receptor binding and signaling cascade activation, and initiation of growth hormone secretion increase that peaks around natural sleep onset timing

As a result, this hastens the degradation of the endothelial wall and the protective function of the microbiota, leading to increased accumulation of pro-inflammatory endotoxins and the prolonged spread of pathogens (Borgogna et al., 2020

Transamination of cysteine yields -mercaptopyruvate (3-mercaptopyruvate, 3-MP) which then reacts with sulfite, (SO 3 2 ), to produce thiosulfate, (S 2 O 3 2 ) and pyruvate

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If, indeed, oxidative stress contributes to sleep homeostasis, this manipulation would be expected to manifest as an alteration in the homeostatic regulation of sleep