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del Cura Gonzalez I Article: ATENCION PRIMARIA

A basket study that implements multiple independent two-stage designs will have a much higher false-positive rate than a typical phase II study and therefore a higher likelihood of being declared effective in at least one basket when in fact the drug is truly ineffective [132]

Results vary, and there is no fixed timeline for recovery

There was only mild congestion in the myocardium and scattered subendocardial ischemic myocytes in rats who had been subjected to grade III intra-abdominal hypertension, and the same morphology was found in rats who had been subjected to grade IV intra-abdominal hypertension (Table 5, Figure 4)

Stronger causal evidence would require inhibitor, knockdown, rescue, or pathway-disruption experiments showing that interference with FAK signaling reduces or eliminates the BPC-157-associated migration response in the specific experimental system