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PubMed Central, Kivity, Shaye, et al

LXR activation increases liver and plasma TG and LDL-C in animal models 14,15,16,17 and humans 18 by upregulating DNL genes 10 , including SREBF1 , ACACA and FASN , and suppressing hepatic LPL activity by inducing ANGPTL3 and APOC3 (ref

10.1007/s10620-018-4946-2

Despite these encouraging findings, most supporting evidence to date arises from in vitro experiments and animal models

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References 1 AbdelraheemE.ThairB.VarelaR
