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In cardiovascular health, it enhances heart function, reduces symptoms of angina, and improves exercise tolerance, particularly in patients with heart failure and ischemic heart disease [39]

Exposure to MA has been shown to disrupt energy metabolism by affecting mitochondrial function and interfering with the utilization of key metabolites, such as pyruvic and lactic acid, for energy production 49,61

Importantly, any of the adverse events that were reported by patients were mild and no more prevalent or serious when compared to the group that received a placebo

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The enzyme transamidinase (AGAT) catalyzes the transfer of an amidino group from arginine to the N-terminal amine of glycine to yield ornithine and guanidinoacetate (GAA)