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High In Vivo Rates of Methionine Biosynthesis in Transformed Human and Malignant Rat Cells Auxotrophic for Methionine

Oxidative stress was assessed by the quantification of protein carbonyls and MDA using Protein Carbonyl Colorimetric and TBARS Assay Kits, respectively (Cayman Chemical, Ann Arbor, MI)

1 2 The Journal of Pharmacology and Experimental Therapeutics

2009;296:E1183E1194

Through the assessment of single nucleotide polymorphisms (SNPs) relevant to oxidative stress, we have highlighted the significant impact of genetic variations in the prooxidant genes, XDH, CYBA, CYP1A1, PTGS2, NOS, MAO and the antioxidant genes, SOD, CAT, GPX, GSS, GLUL, GSR, GSTM1, GSTM5, GSTP1, TXN, and HMOX1 on oxidative stress susceptibility

Kanmogne GD, Schall K, Leibhart J, Knipe B, Gendelman HE, Persidsky Y