bpc 157 human clinical trial evidence safety fda warning Heal or Harm: Body Protective Compound-157 in the Gray Zone An FDA Reversal on Peptides
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doi: 10.1016/j.cmet.2012.04.022

Additionally, it is possible that the concentration and/or duration by which exogenous inflammation was induced in the current study was not efficient in mounting an effective inflammatory response

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There is also a condition called pernicious anaemia where your immune system prevents the cells in your stomach and gut from absorbing B12 from your food

This is more speculative, but it's a valid avenue of inquiry