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The GSH/GSSG, NADPH/NADP + , Grx-SH/Grx-SS, and Trx-SH/Trx-SS are the most important redox couples in maintaining cellular redox homeostasis [13]

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The details of the multistep mechanism postulated for the reaction and the structural motifs of the several enzymes, which have been thoroughly investigated, cannot be described in detail