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One possible explanation is that higher shear stress from faster blood flow increases interactions with vascular endothelial cells, leading to cytotoxicity and cardiovascular toxicity in vivo (Cheng et al., 2023)

HUBERMAN: In fact, one way that BPC-157 creates this increase in angiogenesis, this increase in vasculature, is through upregulation of something called VEGF, V-E-G-F, which is vascular endothelial growth factor
