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Examination of the isotopomer distributions for TCA cycle metabolites showed a significant decrease in the percentage of citrate M5 upon glucose deprivation, indicating decreased reductive carboxylation flux from -ketoglutarate to citrate in glucose-deprived cells 28, 29 (Fig
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Other metabolites that might be involved in SARS-CoV-2 replication are related with the purine metabolism, and it has been suggested that SARS-CoV-2 remodels host folate and one-carbon metabolism to support de novo purine synthesis 41
& Rodriguez-Abreu, D
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[11] It appears to be safe in pregnancy
