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Gamma-H2AX, generated from the rapid phosphorylation of H2AX histone protein at the serine-139 position in early response to a broad range of DNA lesions, is a highly effective biomarker for DNA strand breaks and DNA oxidation and plays a central role in sensing and repairing DNA damage [52,53,54]

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The overexpression of IGF2R can disrupt lysosomal homeostasis and cellular autophagy 31 , accelerating EC progression

Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila

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