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Here we report that in AML cell lines, treatment with the clinically available crisantaspase, Rylaze, upregulates the serine biosynthesis enzymes phosphoglycerate dehydrogenase (PHGDH) and phosphoserine aminotransferase (PSAT1) through activation of the Amino Acid Response (AAR) pathway, a cellular stress response mechanism that regulates amino acid metabolism and protein synthesis under conditions of nutrient limitation

H.JiangZ

Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with ENaC-overexpressing mice

Recognizing its symptoms and implementing effective recovery strategies is crucial
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