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In the present study, we screened peripheral blood mononuclear cells (PBMC) from patients with AGS using single cell RNA sequencing (scRNA-seq), targeted metabolomic and validated our findings in in vitro models for AGS to reveal potentially new cellular mechanisms relevant to the pathogenesis

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NAD is essential in regulating inflammation that damages DNA and corrects existing damage

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The conflicting findings regarding M1 and M2 macrophage polarization suggest that the effects of NAC may be context-dependent, influenced by factors such as concentration, cell type, and specific microenvironmental conditions

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