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The results from a controlled double-blind trial of 30 patients revealed that the supplementation of a formulation containing selenium with vitamins A, C, and E (Se-ACE) did not have any remarkable curative effect compared to a placebo 108

Although HQ is the gold standard and the most commonly prescribed depigmenting agent for melasma management, its effects may be reversible and concerns regarding its adverse reactions including skin irritation, erythema, contact dermatitis, hypochromia, nail discoloration, and ochronosis persist 21

Studies show that GH administration promotes shifts in fuel utilization toward increased fat oxidation and decreased carbohydrate oxidation, which can enhance endurance performance by preserving glycogen stores for high-intensity efforts