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Free Radic Biol Med 65C:9971004

The cytosolic enzyme is encoded by the SHMT1 gene on chromosome 17 and the mitochondrial enzyme is encoded by the SHMT2 gene on chromosome 12

Myelin-derived FFAs activate nuclear receptors LXR and PPAR, inducing cholesterol efflux transporter ATP binding cassette subfamily A member 1 (ABCA1) expression to promote reverse cholesterol transport and suppress inflammation (83,84)

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