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d ) Heat map of normalized gene expression of selected markers to identify major cell lineages

A.KowluruA.MishraM.KumarB

Histone modifications and drug resistance Histone acetyltransferases (HATs) Many lysine residues on histone tails are capable of acetylation, and studies have shown that histone acetylation contributes to cancer development by regulating intracellular pH and affecting the gene transcriptional activity and chromatin structure

Most of these tools are used in preclinical studies [115]

Flubendazole, an antimalarial drug, inhibits SLC7A11/GPX4, promoting ferroptosis in castration-resistant prostate cancer (Zhou et al., 2021)

All reads were taken in technical triplicate