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Activates AMPK (The Metabolic Master Switch) MOTS-C activates AMP-activated protein kinase (AMPK) often called the metabolic master switch. AMPK activation: Increases glucose uptake into cells (improving insulin sensitivity) Enhances fat oxidation (fat burning) Increases mitochondrial biogenesis (creating new, healthy mitochondria) Reduces inflammation Promotes autophagy (cellular cleanup and renewal) This is the same pathway activated by exercise and calorie restriction two of the most powerful interventions for metabolic health and longevity

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Here we show that part of therapeutic effect of artificial tears supplemented with L-carnitine likely stems from its inhibition of TRPV1-induced keratocyte transdifferentiation into myofibroblasts

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doi:10.1001/jama.2023.21835 Nissen, S