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234,235,236,237 Unfortunately, tumor cells often remodel the tumor immune microenvironment through various mechanisms to achieve immune evasiveness, 238 such as reducing tumor antigen presentation, decreasing the infiltration or function of tumor-inhibitory immune cells, and promoting the infiltration of immunosuppressive cells

Sasaki K, Morita K, Kantarjian H, Garcia-Manero G, Jabbour E, Ravandi F, Konopleva M, Borthakur G , Wierda W, Daver N, Takahashi K, DiNardo C, Bravo GM, Issa GC, Pierce SA, Soltysiak KA, Tingen MS, Cortes JE