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doi:10.3389/fnut.2019.00093

Here are a few possible side effects: Allergic Reaction

Dosage may be reduced to 0.5 mL weekly in patients experiencing gastrointestinal intolerance or increased to a maximum of 2 mL twice weekly for short-term metabolic intensification when supervised by a qualified clinician
It works by blocking an enzyme called NNMT (nicotinamide N-methyltransferase)

Patients with chronic kidney and cardiovascular diseases have a higher risk of fatality, especially if the water retention symptoms are significantly high or have worsened

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