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Heller, W., Musil, H

Two 2013 systematic reviews of interventions concluded that the modest benefit of propionyl-L-carnitine on walking performance was equivalent or superior to that obtained with drugs approved for claudication in the US (e.g., pentoxyphylline, cilostazol) yet inferior to improvements seen with supervised exercise interventions (69, 70)

L., and Sun, T

A Turkish study, on the other hand, showed that supplementing 3-4 grams of L-carnitine per day increased time to exhaustion and lowered the pulse in professional soccer players

Effect of dietary lipid, carnitine and exercise on lipid profile in rat blood, liver and muscle

More recent trials have associated oral propionyl-L-carnitine supplementation (2 g/day for several months) with improved walking distance and claudication onset time (66, 67), as well as with higher pain-free walking distance and higher ankle-brachial index (a diagnostic measure of peripheral arterial disease) (68)